Haworth, Brian T. Sutch, Rebecca M. Romero Objectives To evaluate faculty-led discussion meetings (with about eight students) conducted face-to-face (in-class) or by synchronous, real-time videoconference (online), in a biopharmaceutics course taught in a facilitated problem-based learning (PBL) format. Methods Three methods were used to compare in-class versus online discussion sessions for two semesters. The first method involved three parameters that measured the quality of interactions between faculty (facilitator) and student (Fc–St), participation of students in the discussions (Par), and student–student interactions (St–St). The second method assessed student’s perceptions of the discussions with surveys. The third method mapped the interactions (a sociogram) between faculty (facilitator) and students in a discussion. Results There were significantly lower scores for Par and St–St (P < 0.05)>
Biological aim and pharmacology off curcumin
Book ChapterAsma El-Magboub ,Pornchai Rojsitthisak, Chawanphat Muangnoi, Wisut Wichitnithad, Rebecca Meters. Romero, Ian S Haworth Curcumin is the big part of the new reddish color from turmeric, an Indian spruce which is extracted from the brand new rhizome of tropical bush Curcuma longa, and that belongs to the Zingiberaceae family relations. Inside chapter, we discuss the pharmacological situations from curcumin and you can explore the newest molecular basics of these products. We next opinion the new demonstrated and you can potential medical spends off curcumin. Curcumin is known usually as a therapeutic representative, however, its system regarding action are outlined. This new pharmacological outcomes of curcumin be seemingly the consequence of an excellent synergism out-of sites out of weakened biochemical relationships that have multiple physiological aim for the interrelated signaling routes. Such objectives become nutrients like cyclooxygenase, lipoxygenase and you may proteins kinases, and transcription issues instance NF-?B, STAT and you will Nrf2. Modulation of them molecules influences downstream affectors that produce brand new antiinflammatory, antioxidant, chemopreventive, anticancer, and you may antimicrobial activities from curcumin. Such effects was looked at from inside the health-related samples of curcumin to possess pain and you may inflammatory problems, cancer, Alzheimer situation, aerobic infection, and all forms of diabetes. The brand new trials purchased varying dosage from curcuminwith more wavelengths and you may period, into the general completion one to large dosages off curcumin from the quantity of g must see therapeutic outcomes. Find out more
Curcumin: Synthesis, Emerging Role for the Pain Management and you can Wellness Implications
Book Section Examples of plant-derived pharmaceuticals which have get to be the attention out-of continuous and you can great search and you can creativity interest have, yet, come slightly scarce. Just after Schweiz damer til Г¦gteskab a long period, the last two decades were described as a great 100-bend increase in what number of medical posts wrote a-year you to are out of significance on use of curcumin when you look at the biomedicine. Find out more
Structure, synthesis and physical situations off curcumin prodrugs
Book ChapterAsma Este-Magboub ,Pornchai Rojsitthisak, Chawanphat Muangnoi, Wisut Wichitnithad, Rebecca Meters. Romero, Ian S Haworth Curcumin has some prospective pharmacological effects and might has healing apps in a lot of disease states, while the chatted about in more detail in the earlier part. But not, the possibility medical efficacy from curcumin is bound by the their physicochemical attributes of terrible liquid solubility and you will imbalance, and this end up in reasonable bioavailability. Prodrugs out of curcumin promote a method to improvement of the biopharmaceutical and you will pharmacokinetic properties, and can even allow exploitation of one’s pharmacological outcomes of curcumin. Within chapter, we earliest review the physicochemical and you will pharmacokinetics regarding curcumin. I next describe the design of curcumin prodrugs that have improved water solubility and you can improved agents balances and this can be translated to free curcumin abreast of bioactivation inside the vivo. I focus on current victory in this region, which have a concentrate on the framework, synthesis and you may analysis of prodrugs centered on promoieties along with proteins, essential fatty acids, nucleic acids, dicarboxylic acids, and you may polymeric product like hyaluronic acid and you can polyethylene glycol. Which chapter has the reason behind optimisation of your own physicochemical and you can biopharmaceutical qualities therefore the biological things regarding curcumin prodrugs, towards objective having fun with of them curcumin types inside scientific software. Read more
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